|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
[Polymorphism of the serotonin receptor (5-HTR2A) gene and verbal fluency in normalcy and schizophrenia].
|
12624948 |
2003 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
With regard to the serotonergic system, 5-HT1A and 5-HT2A receptors have been studied in the context of cognitive functions in schizophrenia.
|
29896132 |
2018 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
While further research into the molecular mechanisms underlying this interaction is needed, our results underscore the role of 5-HTR in PPI modulation and further implicate the 5-HTR1A G-1019C and the 5-HTR2A T102C polymorphisms in the pathophysiology of schizophrenia.
|
19352591 |
2009 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We performed primer extension assays to measure relative expression of allele-specific HTR2A transcripts in mRNAs isolated from the prefrontal cortex of 31 individuals with schizophrenia and from peripheral lymphocytes (PBLs) of 31 healthy individuals heterozygous for 102T/C.
|
17069769 |
2006 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We looked for an association between schizophrenia and this variant of the 5-HT2a-receptor gene in a large multicentre study.
|
8622505 |
1996 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We investigated the impact of three 5-HT(2A)R polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients.
|
18420180 |
2008 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We hypothesize that the 5-HT2A receptor gene is a modifier gene of schizophrenia and suggest that additional studies are warranted.
|
23063294 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We have recently shown that the linked serotonin-2A receptor (5-HT(2A)R) A-1438 G and T102C polymorphisms modulate PPI in schizophrenia patients.
|
19545856 |
2009 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD.
|
23404241 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found a significant association of A1438G of 5-HTR2A with schizophrenia in Malays.
|
20623453 |
2010 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We evaluated whether MIN-101, a molecule that combines sigma-2 antagonism and 5-HT2A antagonism, might improve cognitive deficits in individuals with moderate to severe negative symptoms in schizophrenia.
|
29873956 |
2019 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We detected nominal significant association with schizophrenia for several haplotype tag SNPs (htSNPs) at HTR2A, although the significance was lost after multiple test corrections.
|
17125970 |
2007 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We detected 7 single nucleotide polymorphisms (SNPs) on 13q14, one (rs6313) present at the HTR2A locus and the other 6 at the KPNA3 locus, among 124 British family trios consisting of mother, father and affected offspring with schizophrenia.
|
15882913 |
2005 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
We analyzed the 5-HT(2A)R A-1438G, T102C, and H452Y polymorphisms and assessed startle reactivity, habituation, and PPI of ASR in 68 Caucasian schizophrenia inpatients.
|
18420180 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
We analysed the 5-HTR2A T102C and A-1438G polymorphisms in clinically stable schizophrenia patients (SPs) and healthy volunteers (HVs).
|
17617023 |
2007 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Variants at the gene encoding for the 5-hydrosytryptamine (serotonin) receptor 2A (HTR2A) have been associated with many psychiatric disorders such as schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive-compulsive disorder, eating disorders, and Alzheimer's disease.
|
17691947 |
2007 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To use a hierarchical approach to determine the functional effects of this single-nucleotide polymorphism on 5-HT2AR messenger RNA and protein expression, on prefrontal phenotypes linked with genetic risk for schizophrenia, and on treatment with olanzapine.
|
23842608 |
2013 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Thus genetic polymorphisms of two central 5-HT receptors (5-HT2A and 2C), at which many of the newer antipsychotic drugs act, are prime candidates for pharmacogenetic analysis of the effects of these drugs in the treatment of schizophrenia.
|
15953671 |
2005 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Three polymorphisms in HTR2A, one silent (C102T), one that alters the amino acid sequence (his452tyr) and one in the promoter region (A-1437G) were investigated in 136 patients refractory or intolerant to treatment with typical antipsychotics and with a DSM-IIIR diagnosis of schizophrenia.
|
11317228 |
2001 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Three CpG sites were hypermethylated in schizophrenia (cg5 <i>p</i> = 0.028, cg7 <i>p</i> = 0.021, cg10 <i>p</i> = 0.017) and <i>HTR2A</i> polymorphisms rs6314 (<i>p</i> = 0.008) and rs6313 (<i>p</i> = 0.026) showed genetic association with schizophrenia.
|
28054990 |
2017 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study investigated whether the efficacy of aripiprazole can be predicted by functional HTR2A A-1438G/rs6313" genes_norm="3356;54187;6302">T102C polymorphisms (rs63311/rs6313) as modified by clinical factors in Han Chinese hospitalized patients with acutely exacerbated schizophrenia.
|
19387614 |
2009 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study does not support an association between the 5-HT2 receptor gene locus and schizophrenia or subgroups based on treatment response.
|
8925254 |
1996 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This finding suggests that genetic predisposition to schizophrenia may be affected by a functional 5-HT2A receptor variant that is in linkage disequilibrium with 102T/C.
|
8655141 |
1996 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the interaction between 5-HTTLPR and 5-HTR2A polymorphisms may not contribute to susceptibility to schizophrenia as well as some clinical factors such as antipsychotic response, at least in the Korean population.
|
15893580 |
2005 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results add experimental evidence to the view that RHA-I rats represent a model with predictive and construct validity of some dopamine and 5-HT2A receptor-related features of schizophrenia.
|
28154892 |
2017 |